Our research data
Effectiveness
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Strong
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Notable
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Minor
Supplement Category
AIWO NCT
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Immune Health
+A potent antioxidant which neutralizes the effect of free radicals and strengthens your immune system and helps evade pathogens.
Betaine in Inflammation: Mechanistic Aspects and Applications
https://pubmed.ncbi.nlm.nih.gov/29881379/?from_term=trimethylglycine+antiinflammatory+&from_pos=1
Effect of Supplementation with Trimethylglycine (Betaine) and/or Vitamins on Semen Quality, Fertility, Antioxidant Status, DNA Repair and Welfare of Roosters Exposed to Chronic Heat Stress
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719041/
Betaine Inhibits Interleukin-1β Production and Release: Potential Mechanisms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255979/
Spicing Up of the Immune System by Curcumin
https://link.springer.com/article/10.1007/s10875-006-9066-7
Curcumin and tumor immune-editing: resurrecting the immune system
https://celldiv.biomedcentral.com/articles/10.1186/s13008-015-0012-z
CURCUMIN AND AUTOIMMUNE DISEASE
https://link.springer.com/chapter/10.1007/978-0-387-46401-5_19
Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy
https://pubmed.ncbi.nlm.nih.gov/33403940/
Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses
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Lung Health
+It strengthens the body’s defense mechanisms. Taking into account the lung protective and immune strengthening roles of niacin, it could be used as an adjunct treatment for COVID-19 patients. It prevents lung tissue damage and reduces viral replication.
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets
https://academic.oup.com/bib/article/22/2/1279/5964187?login=true
Sufficient niacin supply: the missing puzzle piece to COVID-19, and beyond?
Be well: A potential role for vitamin B in COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428453/
Curcumin as a Potential Treatment for COVID-19
https://www.frontiersin.org/articles/10.3389/fphar.2021.675287/full
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Heart Health
+It is known to facilitate methylation processes and support healthy Homocysteine levels which is important for the health of the cardiovascular system.
Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies
Characterization of Metabolic Responses to Healthy Diets and Association With Blood Pressure: Application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a Randomized Controlled Study
Dietary Choline and Betaine Intakes and Risk of Cardiovascular Diseases: Review of Epidemiological Evidence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347848/
Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women
https://academic.oup.com/jn/article/133/12/4135/4687457
Choline and Betaine in Health and Disease
https://pubmed.ncbi.nlm.nih.gov/20446114/
Novel Heart Failure Therapy Targeting Transcriptional Pathway in Cardiomyocytes by a Natural Compound, Curcumin
https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-09-1012/_article/-char/ja
Niacin and heart disease prevention: Engraving its tombstone is a mistake 7.Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease
https://pubmed.ncbi.nlm.nih.gov/28927896/
Betaine Supplementation Moderately Increases Total Cholesterol Levels: A Systematic Review and Meta-Analysis
https://pubmed.ncbi.nlm.nih.gov/31809615/ -
Skin health
+The anti-inflammatory and anti-aging properties can decrease UV damage and clear up skin issues.
Beneficial role of curcumin in skin diseases
https://pubmed.ncbi.nlm.nih.gov/17569219
Nicotinic acid/niacinamide and the skin
https://pubmed.ncbi.nlm.nih.gov/17147561
The ability of betaine to reduce the irritating effects of detergents assessed visually, histologically and by bioengineering methods
https://pubmed.ncbi.nlm.nih.gov/12535285/
The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively"
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Liver Health
+It is clinically proven with liver detoxification and helps in lowering blood sugar.
Role of betaine in liver disease-worth revisiting or has the die been cast?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579752/
Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials
https://pubmed.ncbi.nlm.nih.gov/30949432/
The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials
https://pubmed.ncbi.nlm.nih.gov/31987259/
Niacin
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Brain Health
+It promotes a positive mood,improves mental health, reduces symptoms of seasonal depression and improves memory.
Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications
www.ncbi.nlm.nih.gov/pmc/articles/PMC6412771/
Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study
https://academic.oup.com/ajcn/article/106/4/1032/4652049
Benefits of curcumin in brain disorders
https://pubmed.ncbi.nlm.nih.gov/31185140/
The effect of curcumin (turmeric) on Alzheimer's disease: An overview
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/
Betaine in the Brain: Characterization of Betaine Uptake, its Influence on Other Osmolytes and its Potential Role in Neuroprotection from Osmotic Stress
https://pubmed.ncbi.nlm.nih.gov/28918494/
The betaine/GABA transporter and betaine: roles in brain, kidney, and liver
https://pubmed.ncbi.nlm.nih.gov/24795654/