Our research data
We spent years researching the most effective supplements in the markets - cutting through the noise and separating truths from fads. Once we knew the science, we set to work to source the best ingredients. We provide complete transparency on our ingredients and point you to research backing any claims.
Effectiveness
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Strong
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Notable
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Minor
Supplement Category
AiWO Vitamin K2-MK4
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Heart Health
+Vitamin K-2 lowers the risk of cardiovascular damage and improves overall heart health.
The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585988/
Vitamin K2: A Vitamin that Works like a Hormone, Impinging on Gene Expression
https://www.intechopen.com/chapters/65878
Vitamin K2—a neglected player in cardiovascular health: a narrative review
https://pubmed.ncbi.nlm.nih.gov/34785587/
Menatetrenone
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Immune Health
+It helps to neutralize the effect of free radicals and Supports metabolic health
Immunomodulatory effect of vitamin K2: Implications for bone health
https://www.mdpi.com/2227-9717/8/7/870/htm
Determination of Vitamins K1, K2 MK-4, MK-7, MK-9 and D3 in Pharmaceutical Products and Dietary Supplements by TLC-Densitometry
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Brain Health
+It reduces anxiety and Depression
Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Healthhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494092/
The Relationships Between Vitamin K and Cognition: A Review of Current Evidence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436180/
Menatetrenone
https://www.sciencedirect.com/topics/medicine-and-dentistry/menatetrenone
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Bone Health
+Vitamin K2 and its key isomers MK-7 and MK-4 to be very effective in bone health and heart disease prevention. K2MK4 helps in strengthening bones & increasing bone density.
Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566462/
Vitamin K2 in bone metabolism and osteoporosis
https://pubmed.ncbi.nlm.nih.gov/15771560/
Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis
https://pubmed.ncbi.nlm.nih.gov/17274493/
Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis
https://pubmed.ncbi.nlm.nih.gov/10750566/
Menatetrenone
https://www.sciencedirect.com/topics/medicine-and-dentistry/menatetrenone
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Circulatory Health
+It plays an important role in making proteins for blood clotting and prevents excessive bleeding from both inside and outside the body.
Controllable vitamin K deficiency under high-dose oral menatetrenone administration - a case report
https://pubmed.ncbi.nlm.nih.gov/29609692/
Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency
https://pubmed.ncbi.nlm.nih.gov/11846334/
Vitamin K
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Anti-Cancer
+It prevents the growth and metastasis of cancers and downregulates the expression of hepatoma-derived growth factor (HDGF) by suppressing cellular growth.
Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/23225445/
Efficacy and safety of sorafenib plus vitamin K treatment for hepatocellular carcinoma: A phase II, randomized study
https://pubmed.ncbi.nlm.nih.gov/33481328/
Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue
https://pubmed.ncbi.nlm.nih.gov/19639210/
Enhanced therapeutic efficacy of vitamin K2 by silencing BCL-2 expression in SMMC-7721 hepatocellular carcinoma cells